The damage of bone tissue occurs due to trauma, osteonecrosis and tumors. The treatments for the bone loss due to thee above conditions are challenging. In India, the foremost problem is that a majority of the patients do not opt for synthetic bone graft due financial reasons. It reduces their quality of life therefore leading to jaw fracture or losing the teeth in future. We would like to address the problem by bringing universal and customized bone graft which will not only eliminate the use of autograft with the second surgical site but will also bring down the cost and healing time. Recently, we have done extensive work on 3D scaffolds and the porous membrane prepared by various techniques and then done in-vitro and preliminary in-vivo trials of the same in animal models. A novel 3D scaffold has been developed and is being further tested. Our aim through this project is to provide an effective treatment for the base of the pyramid by bringing the cost to at least 10 times lower than other products available and thereby allow penetration of these products to the lives of people having low incomes. The technology that we are developing for the regeneration of bone will be customized to every patient of any age and will be able to repair large and complete restoration of bone structure, for dental and orthopedic conditions.